The Importance of Magnesium in Clinical Healthcare

Editorial Review

The Importance of Magnesium in Clinical Healthcare

Gerry K. Schwalfenberg and Stephen J. Genuis

Scientifica, Volume 2017, Article ID 4179326,

JACO Editorial Reviewer: Deanna L. O’Dwyer, DC

Published: June 2018
Journal of the Academy of Chiropractic Orthopedists
June 2018, Volume 15, Issue 2

The original article copyright belongs to the original publisher. This review is available from: ©2010 O’Dwyer and the Academy of Chiropractic Orthopedists. This is an Open Access article which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Authors’ Abstract:

Background: Magnesium is an essential element required as a co-factor required in over 300 enzymatic reactions and metabolic pathways. It is estimate that up to two-thirds of the Western population are not attaining the RDA of magnesium.

Methods: Review of magnesium in the literature was assessed via MEDLINE and PubMed. Written books, as well as, conference proceedings were also reviewed. A traditional integrated review format with Level 1 evidence to support the use of magnesium in the prevention or treatment of many common ailments. These could include, although not limited to: migraine, metabolic syndrome, diabetes (I and II), hyperlipidemia, asthma, premenstrual syndrome, preeclampsia, various cardia arrthymias, attention deficit/hyperactivity and other, as yet, undiscovered ailments. Magnesium may also be influential for the prevention of renal calculi, cataract formation; as an adjunct to depression. The possibilities are limitless.

Results: Supplementation with as little as 300mg of various forms of magnesium have been shown to improve health and decrease disease states.

Conclusions: The role of magnesium is more far-reaching than previously considered. Traditional medical practitioners should consider magnesium supplementation as an adjunct to well rounded healthcare, especially in certain chronic disease states.

Clinical Relevance: Many chronic illness and disease processes are directly related to sublimial, chronic hypo -magnesia.

JACO Editorial Summary:

This article is written by authors from the Dept of Family Medicine, Faculty of Medicine, University of Alberta and the University of Calgary.

The focus of the study was to demonstrate the efficacy of magnesium supplementation in various disease states to medical practitioners who might otherwise be uninformed to the benefits of nutritional management of disease.

Magnesium is the fourth most common mineral after calcium, sodium and potassium, in the human body. It is also the second most common intercellular cation after potassium. Up to 68% of all Americans are deficient in magnesium. The RDA for magnesium varies from as low as 30 mg in infants to 420 mg for a 51+ year old male.

Processed, preserved and organic foods are generally deficient in magnesium putting the m majority of Americans who partake in the Standard American Diet, at risk.

Many factors influence the efficiency with which magnesium is absorbed and utilized in the human body. These factors include, but are not limited to decreased absorption due to Vitamin D deficiency, certain common medications (antibiotics, antacids, antihypertensive drugs), pesticides which chelate the minerals. There is excess excretion due to alcohol use and the presence of diabetes I and II. Decreased plasma concentrations due to smoking. Decreased absorption due to the normal aging process.

The role of magnesium in cellular function ranges from contributing to the synthesis of ATP, binding to ATP to yield the bioactive form of Mg-ATP and binding site for up to 3571 human proteins. Magnesium’s biologic half life is about 42 days (1000 hours).

Disease states, generally, would be improved with improved nutritional protocols.


Prudent and further investigation must be conducted to best accommodate the patient and the disease states. The practitioner should take great care to decide which form of magnesium would be amenable to the particular disease or deficiency.